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Lithium toxicity is a significant concern for individuals taking this medication, commonly used for the treatment of bipolar disorder. Typically, serum lithium levels above 1.5 mEq/L can be associated with mild toxicity; however, severe toxicity often occurs at levels around 2.0 mEq/L and above.

A serum level of 2.5 mEq/L is generally recognized as the threshold at which serious, potentially life-threatening symptoms may occur, indicating severe toxicity. At this level, patients may exhibit critical signs such as significant neurological impairment, renal dysfunction, and potential cardiac issues. Hence, while lithium levels above 1.5 mEq/L can indicate toxicity, reaching or exceeding a serum level of 2.5 mEq/L is where clinicians will be particularly concerned about the potential for severe and acute health crises.

Therefore, recognizing that lithium toxicity typically begins to present severe symptoms around the 2.5 mEq/L threshold helps guide monitoring and intervention strategies for those receiving lithium therapy.